Endocrine Abstracts

Chronic sub-clinical inflammation is associated with both type 2 diabetes and related vascular complications which is coupled with pro-inflammatory markers, such as IL-6, TNF-alpha and C-reactive protein (CRP). Resistin is the latest protein to be linked with inflammation and insulin resistance in obesity. Adipose tissue has been previously established as a source of circulating resistin, TNF-alpha and IL-6. As our previous studies demonstrated a correlation between serum resi...

Type 2 diabetes (T2DM) is associated with insulin resistance and chronic sub-clinical inflammation. Pro-inflammatory cytokines produced from adipose tissue are secreted as part of the innate immune response and also associated with insulin resistance. In contrast, adipocyte derived adiponectin is associated with insulin sensitivity and also has anti-inflammatory properties. Hence fat may represent a site for mediating the innate immune response. We therefore investigated a mec...

Adiponectin is an adipocyte derived-hormone, associated with insulin sensitivity and a lower risk of atherosclerosis. As central rather than gluteo-femoral fat is known to increase the risk of type 2 diabetes (T2DM) and cardiovascular disease we investigated the mRNA and protein expression of adiponectin in human adipose tissue depots. RNA and protein was extracted using a cohort of 46 human adipose tissue samples (non-diabetic (ND) (age: (mean plus/minus SD) 44.33 plus/minus ...

(This poster is based on OC18.)...

Adiponectin (acrp30) is an adipocyte derived-hormone, associated with insulin sensitivity and lower risk of atherosclerosis. Plasma adiponectin concentrations are decreased in obese and type 2 diabetic subjects with insulin resistance. As central rather than gluteo-fermoral fat is known to increase the risk of type 2 diabetes and cardiovascular disease we investigated the expression of adiponectin in human adipose tissue depots. We examined expression of adiponectin mRNA level...

The renin-angiotensin system (RAS) is a key factor in the regulation of blood pressure and therefore its' blockade may reduce the vascular complications which arise with polycystic ovary syndrome (PCOS). Adipose tissue expresses all the components of the RAS system that includes the pre-prohormone angiotensinogen (AGT) and its' active metabolite angiotensin II (ANG II), which mediates vasoconstriction and electrolyte balance and as such may contribute to obesity associated hyp...